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RNA. 2003 Jan;9(1):44-51.

The crystal structure of a 26-nucleotide RNA containing a hook-turn.

Szép S, Wang J, Moore PB.

Source

Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA.

Abstract

A crystal structure has been obtained for a 26-nucleotide RNA that contains the loop E sequence from Chromatium minutissimum. Rather than having a loop E-like conformation, it consists of an A-form helix that splits into two separate strands following a sheared A-G base pair. The backbone of the strand containing the G of the A-G pair makes a turn of almost 180 degrees in the space of two nucleotides, and then interacts with the minor groove of the helix from which it originates. Similar structures, which we call hook-turns, occur in 16S and 23S rRNAs. They are found at places where the two strands of a helix separate at an A/G juxtaposition to interact with other sequences.

PMID:: 12554875; [PubMed - indexed for MEDLINE]
PMCID:: PMC1370369

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Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

Research Support, U.S. Gov't, P.H.S.

MeSH Terms

Substances

RNA

Grant Support

GM2278/GM/NIGMS NIH HHS/United States

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Structures reported by this article

Crystal Structure Analysis Of A 26mer Rna Molecule, Representing A New Rna Motif, The Hook-Turnÿ

PDB: 1MHK

Source:

Method: X-Ray Diffraction

Resolution: 2.5 Å

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