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J Virol. 2003 Feb;77(4):2757-61.

Identification of a TAP-independent, immunoproteasome-dependent CD8+ T-cell epitope in Epstein-Barr virus latent membrane protein 2.

Author information

  • 1Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, UK.

Abstract

We have identified an HLA-A2-restricted CD8(+) T-cell epitope, FLYALALLL, in the Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2), an important target antigen in the context of EBV-associated malignancies. This epitope is TAP independent, like other hydrophobic LMP2-derived epitopes, but uniquely is dependent upon the immunoproteasome for its generation.

PMID:
12552018
[PubMed - indexed for MEDLINE]
PMCID:
PMC141109
Free PMC Article

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