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Biol Psychiatry. 2003 Jan 15;53(2):184-7.

Proton spectroscopy in medication-free pediatric attention-deficit/hyperactivity disorder.

Author information

  • 1Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.

Abstract

BACKGROUND:

The frontal-striatal pathway has been previously implicated in the neuropathology of attention-deficit/hyperactivity disorder (ADHD). Hence, we used proton magnetic resonance spectroscopy (1H-MRS) to examine metabolite levels in the prefrontal cortex of children with ADHD.

METHODS:

Nine age- and gender-matched case-control pairs were examined, ages 7 to 16 years. A long-echo 1H-MRS scan was acquired from the right prefrontal cortex and left striatum in all subjects. Compounds that can be visualized with 1H-MRS include N-acetyl-aspartate (NAA), glutamate/glutamine/gamma-aminobutyric acid (Glx), creatine/phosphocreatine (Cr), and choline compounds (Cho).

RESULTS:

Frontal-striatal glutamatergic resonances were elevated in the children with ADHD as compared to healthy control subjects. No differences were noted in NAA, Cho, or Cr metabolite ratios.

CONCLUSIONS:

These findings suggest that frontal-striatal Glx resonances may be increased in children with ADHD in comparison with healthy control subjects.

PMID:
12547476
[PubMed - indexed for MEDLINE]
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