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Drug Discov Today. 2002 Jul 15;7(14):759-65.

High-throughput protein expression for the post-genomic era.

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  • 1Vertex Pharmaceuticals, 130 Washington Street, Cambridge, MA 02139, USA. chambers@vrtx.com


In the past, protein expression has been perceived as the principle bottleneck in protein characterization and structure determination. The challenge now is to rapidly express large numbers of genes in the search for new drug targets and therapeutic proteins encoded by the human genome. In this competitive environment, several high-throughput expression strategies for protein production are being used to industrialize the process of protein expression.

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