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Drug Discov Today. 2002 Sep 15;7(18 Suppl):S131-5.

High-throughput cell analysis using multiplexed array technologies.

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  • 1Virtual Arrays, 1190 Bordeaux Drive, Sunnyvale, CA 94089, USA.

Abstract

The desire for more biologically relevant data from primary screening has resulted in a dramatic increase of cell-based assays in HTS labs. Consequently, new cell-array technologies are being developed to increase the quality and quantity of data emerging from such screens. These technologies take the form of both positional and non-positional formats, each with their own advantages. Notably, screens using these technologies generate databases of high-quality data that can be analyzed in ways currently not possible. The power of cell-based assays combined with new array and analytical technologies will enable the condensation of serial drug discovery processes, thereby decreasing the time and cost of taking a hit compound into clinical trials. Here, we compare array strategies being developed towards the goal of integrating multiplexed cell-based assays into HTS.

PMID:
12546879
[PubMed - indexed for MEDLINE]
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