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Dig Liver Dis. 2002 Nov;34(11):775-80.

Autonomic imbalance during the day in patients with inflammatory bowel disease in remission. Evidence from spectral analysis of heart rate variability over 24 hours.

Author information

  • 1Gastroenterology Department, University Hospital of Heraklion, Medical School, University of Crete, Greece. mouzas@med.uoc.gr

Abstract

BACKGROUND:

Autonomic function in inflammatory bowel disease has not yet been studied by means of analysis of 24-hour heart rate variability.

AIM:

To measure heart rate variability in inflammatory bowel disease patients in remission.

PATIENTS AND METHODS:

Study population comprised 27 patients with inflammatory bowel disease in remission and 28 healthy, sex- and age-matched controls. Two frequency ranges were analysed: low frequency (0.06-0.15 Hz) and high frequency (0.15-0.40 Hz).

RESULTS:

Mean values of low frequency and low frequency/high frequency ratio were lower in patients than in controls (p < 0.001). High frequency in patients tended to be higher than in controls (p = 0.09). The only factor that had a marginal effect on heart rate variability indexes was age. In high frequency, there was a significant time effect (p = 0.001) for both groups. There was also a significant time effect in low frequency/high frequency ratio in both groups (p < 0.001). During daytime, the mean values in low frequency/high frequency ratio were lower in patients than in controls (p < 0.001).

CONCLUSIONS:

There is a shift in the autonomic balance in patients with inflammatory bowel disease in remission towards a condition of relative parasympathetic predominance, which, in the first place, reflects a sympathetic pullback. This imbalance has a circadian rhythm and it is more pronounced during the day.

PMID:
12546512
[PubMed - indexed for MEDLINE]
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