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    Science. 2003 Jan 24;299(5606):574-7.

    Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice.

    Tang Y, Katuri V, Dillner A, Mishra B, Deng CX, Mishra L.

    Source

    Laboratory of Developmental Biology, Department of Medicine, Georgetown University, Washington, DC 20007, USA.

    Abstract

    Disruption of the adaptor protein ELF, a beta-spectrin, leads to disruption of transforming growth factor-beta (TGF-beta) signaling by Smad proteins in mice. Elf-/- mice exhibit a phenotype similar to smad2+/-/smad3+/- mutant mice of midgestational death due to gastrointestinal, liver, neural, and heart defects. We show that TGF-beta triggers phosphorylation and association of ELF with Smad3 and Smad4, followed by nuclear translocation. ELF deficiency results in mislocalization of Smad3 and Smad4 and loss of the TGF-beta-dependent transcriptional response, which could be rescued by overexpression of the COOH-terminal region of ELF. This study reveals an unexpected molecular link between a major dynamic scaffolding protein and a key signaling pathway.

    PMID:
    12543979
    [PubMed - indexed for MEDLINE]
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