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Br J Ophthalmol. 2003 Feb;87(2):147-8.

Community treatment with azithromycin for trachoma is not associated with antibiotic resistance in Streptococcus pneumoniae at 1 year.

Author information

  • 1The Francis I Proctor Foundation and the Department of Ophthalmology, University of California, San Francisco, 94143, USA. bgaynor@itsa.ucsf.edu

Abstract

AIMS:

To determine if macrolide resistant Streptococcus pneumoniae will be a major concern in areas that receive annual mass azithromycin distributions for trachoma.

METHODS:

A cross sectional survey was conducted of nasopharyngeal S pneumoniae isolates for susceptibility to azithromycin 1 year after administering a single dose of azithromycin to treat trachoma in a village in Nepal.

RESULTS:

S pneumoniae was isolated from 50 (86%) of 57 nasopharyngeal cultures and no resistance to azithromycin was detected.

CONCLUSION:

The authors were unable to demonstrate that mass azithromycin therapy for trachoma produced macrolide resistant S pneumoniae that persists until the next scheduled annual treatment.

PMID:
12543738
[PubMed - indexed for MEDLINE]
PMCID:
PMC1771508
Free PMC Article
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