Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Biochem Biophys Methods. 2002 Dec 31;54(1-3):415-22.

Enantiomeric resolution of a novel chiral cannabinoid receptor ligand.

Author information

  • 1Department of Pharmaceutical Sciences and the Center for Drug Discovery, University of Connecticut, 372 Fairfield Road, Storrs, CT 06269, USA.

Abstract

The enantiomeric resolution of a racemic novel cannabinoid receptor ligand conformationally restricted at the southern aliphatic chain was accomplished using a ChiralPak AD column. Both enantiomers were tested for their competitive binding to the rat brain CB1, mouse spleen CB2 and human CB2 receptors. The levorotatory isomer showed exceptionally high affinity for the CB1 receptor with a seven-fold selectivity over CB2.

Copyright 2002 Elsevier Science B.V.

PMID:
12543516
[PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk