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Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1128-33. Epub 2003 Jan 21.

Modular organization of cellular networks.

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  • 1Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103, USA.


We investigated the organization of interacting proteins and protein complexes into networks of modules. A network-clustering method was developed to identify modules. This method of network-structure determination was validated by clustering known signaling-protein modules and by identifying module rudiments in exclusively high-throughput protein-interaction data with high error frequencies and low coverage. The signaling network controlling the yeast developmental transition to a filamentous form was clustered. Abstraction of a modular network-structure model identified module-organizer proteins and module-connector proteins. The functions of these proteins suggest that they are important for module function and intermodule communication.

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