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Arch Dis Child. 2003 Feb;88(2):174-5.

BK virus DNA in CSF of immunocompetent and immunocompromised patients.

Author information

  • 1Professor Alborzi Clinical Microbiology Research Center, Clinical Virology Section, Shiraz University of Medical Sciences, Shiraz, Iran. Behbahani_2000@yahoo.com

Abstract

AIM:

To investigate the possible aetiological role of BK and JC viruses in immunocompetent and immunocompromised children with suspected encephalitis and meningoencephalitis.

METHODS:

The polymerase chain reaction and microplate hybridisation method was employed for the detection of polyomavirus DNA in 266 CSF specimens collected from immunocompetent and immunocompromised patients.

RESULTS:

BK virus DNA was detected in three (2.1%) CSF samples taken from patients aged 2-5 years; two were patients with acute lymphocytic leukaemia without overt neurological symptoms, the other was a patient with suspected encephalitis. BK virus DNA was also detected in two (1.6%) CSF samples taken from older children in the age range 10-16 years; both children had suspected encephalitis. JC virus DNA was not found in any CSF sample from either age group.

CONCLUSIONS:

Detection of BK virus in the CSF of immunocompromised and immunocompetent patients with suspected neurological disease suggests that this virus may have had a pathogenic role in the aetiology of this condition.

PMID:
12538331
[PubMed - indexed for MEDLINE]
PMCID:
PMC1719422
Free PMC Article
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