MPID: MHC-Peptide Interaction Database for sequence-structure-function information on peptides binding to MHC molecules

Bioinformatics. 2003 Jan 22;19(2):309-10. doi: 10.1093/bioinformatics/19.2.309.

Abstract

Summary: Binding of short antigenic peptides to Major histocompatibility complex (MHC) proteins is the first step in T-cell mediated immune response. To understand the structural principles governing MHC-specific peptide recognition and binding, we have developed the MHC-Peptide Interaction Database (MPID), containing sequence-structure-function information. MPID (version 1.2) contains curated x-ray crystallographic data on 86 MHC peptide complexes, with precomputed interaction parameters (solvent accessibility, hydrogen bonds, gap volume and gap index). A user-friendly web interface and query tools will facilitate the development of predictive algorithms for MHC-peptide binding from a structural viewpoint.

Availability: Freely accessible from http://surya.bic.nus.edu.sg/mpid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Database Management Systems*
  • Databases, Protein*
  • Histocompatibility Antigens / chemistry
  • Information Storage and Retrieval / methods
  • Macromolecular Substances
  • Major Histocompatibility Complex*
  • Peptide Fragments / chemistry
  • Peptides / chemistry*
  • Protein Binding
  • Protein Conformation
  • Structure-Activity Relationship*
  • User-Computer Interface

Substances

  • Histocompatibility Antigens
  • Macromolecular Substances
  • Peptide Fragments
  • Peptides