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Genome Biol. 2002;3(12):REVIEWS1035. Epub 2002 Nov 28.

RNAi hushes heterochromatin.

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  • 1Molecular and Cellular Biology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

Abstract

Repeated DNA elements and region-specific protein modifications combine within chromosomes to form a transcriptionally silent chromatin structure called heterochromatin. Recent work in the fission yeast Schizosaccharomyces pombe reveals that RNA is also an integral component of silent heterochromatin, providing a new perspective on how heterochromatin is organized and maintained in eukaryotic cells.

PMID:
12537580
[PubMed - indexed for MEDLINE]
PMCID:
PMC151193
Free PMC Article

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