Your browser version may not work well with NCBI's Web applications. More information here...
1: Genome Biol. 2002;3(12):REVIEWS1035. Epub 2002 Nov 28.Click here to read Click here to read Links

RNAi hushes heterochromatin.

Bailis JM, Forsburg SL.

Molecular and Cellular Biology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

Repeated DNA elements and region-specific protein modifications combine within chromosomes to form a transcriptionally silent chromatin structure called heterochromatin. Recent work in the fission yeast Schizosaccharomyces pombe reveals that RNA is also an integral component of silent heterochromatin, providing a new perspective on how heterochromatin is organized and maintained in eukaryotic cells.

PMID: 12537580 [PubMed - indexed for MEDLINE]

PMCID: PMC151193

Recent Activity