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Genome Biol. 2002;3(12):RESEARCH0081. Epub 2002 Dec 23.

An integrated computational pipeline and database to support whole-genome sequence annotation.

Author information

  • 1Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA. cjm@fruitfly.org

Abstract

We describe here our experience in annotating the Drosophila melanogaster genome sequence, in the course of which we developed several new open-source software tools and a database schema to support large-scale genome annotation. We have developed these into an integrated and reusable software system for whole-genome annotation. The key contributions to overall annotation quality are the marshalling of high-quality sequences for alignments and the design of a system with an adaptable and expandable flexible architecture.

PMID:
12537570
[PubMed - indexed for MEDLINE]
PMCID:
PMC151183
Free PMC Article

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