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Brain Dev. 2003 Jan;25(1):45-50.

Cerebral proton magnetic resonance spectroscopy of a patient with giant axonal neuropathy.

Author information

  • 1Department of Pediatrics and Neuropediatrics, Georg-August-Universit├Ąt, Children's Hospital, Robert-Koch-Strasse 40, 37075 Goettingen, Germany. kbrock@med.uni-goettingen.de

Abstract

Magnetic resonance imaging of a girl with giant axonal neuropathy revealed a progressive white matter disease. In close agreement with histopathological features reported previously, localized proton magnetic resonance spectroscopy at 9 and 12 years of age indicated a specific damage or loss of axons (reduced N-acetylaspartate and N-acetylaspartylglutamate) accompanied by acute demyelination (elevated choline-containing compounds, myo-inositol, and lactate) in white matter as well as a generalized proliferation of glial cells (elevated choline-containing compounds and myo-inositol) in both gray and white matter.

PMID:
12536033
[PubMed - indexed for MEDLINE]
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