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    Sheng Li Ke Xue Jin Zhan. 1999 Jul;30(3):224-6.

    [Research on the mechanism of neuronal apoptosis in Alzheimer's disease and the effects of tetrohydroberberine on the apoptosis]

    [Article in Chinese]

    Xu CQ.

    Department of Neurology, First Affiliated Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou 510080.

    Apoptosis in Alzheimer's disease(AD) was studied by the techniques of immunohistochemistry, neuronal culture and patch clamp. The hippocampal neuronal apoptosis induced by beta-amyloid peptide (beta-AP) and its ionic mechanism were also observed. The results showed that neuronal apoptosis did exist in AD brains and beta-AP might induce the apoptosis by blocking the voltage-dependent K+ and Na+ channels, which were enhanced by nitric oxide(NO). In addition, tetrohydroberbine could protect against the apoptosis induced by beta-AP by reducing hippocampal neuronal intracellar free Ca2+.

    PMID: 12532784 [PubMed - indexed for MEDLINE]

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