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Anticancer Res. 2002 Nov-Dec;22(6A):3421-4.

Polymorphism of IL-1 receptor antagonist gene: role in cancer.

Author information

  • 1Department of Obstetrics and Gynaecology, Humboldt University, Augustenburger Platz 1, D-13353 Berlin, Germany.

Abstract

BACKGROUND:

IL-1-cytokines are strongly involved in carcinogenesis and tumor genesis. In this systematic review we will describe the role of IL-1 RA within the cytokine network and its predictive and prognostic value in cancer.

MATERIALS AND METHODS:

We analysed preclinical and clinical studies.

RESULTS:

A polymorphism is present in intron 2 of the human IL-1RA gene. The IL-1RA allele 2 has an influence on the IL-1RA plasma level. The IL-1 beta level is elevated at the homozygous for IL-1RA, allele 2 (IL-1RN*2). The IL-1 gene cluster polymorphism is associated with gastric cancer. Carriers of IL-1 1B- 511T and IL-1RN*2 homozygotes have an increased risk of developing gastric cancer. Patients with a heterozygosity of allele 2 for IL-1 RA (IL-RA1/2) have an increased risk of cervical cancer. There are negative associations between IL-1 RA polymorphism and the occurrence of ovarian cancer.

CONCLUSION:

The polymorphism of IL-1RA seems to be involved in the induction of different solid tumors.

PMID:
12530098
[PubMed - indexed for MEDLINE]
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