Send to:

Choose Destination
See comment in PubMed Commons below
Physiol Behav. 2002 Dec;77(4-5):683-7.

Importance of nonpharmacological factors in nicotine self-administration.

Author information

  • 1Department of Psychology, University of Pittsburgh, 3131 Sennott Square, 210 Bouquet Street, 15260, Pittsburgh, PA, USA.


There is mounting evidence that nonpharmacological factors critically modulate the effects of several drugs of abuse both in humans and experimental animals. This paper reviews research from this laboratory on one factor that influences the degree to which nicotine is self-administered: environmental stimuli that form the context within which nicotine is taken. The results suggest that the direct, pharmacological actions of nicotine are necessary but not sufficient to explain either the high rates of self-administration exhibited by laboratory animals or cigarette smoking by humans, and that future investigations on the neurophysiological effects of nicotine that underlie smoking behavior must take into account the environmental context within which the behavior occurs.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk