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    Trends Microbiol. 2003 Jan;11(1):21-9.

    The structure and function of drug pumps: an update.

    McKeegan KS, Borges-Walmsley MI, Walmsley AR.

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    Centre for Infectious Diseases, Wolfson Research Institute, Queen's Campus, University of Durham, Stockton-on-Tees, UK.

    Abstract

    Our understanding of the exact mechanisms used by the transmembrane protein pumps that confer cellular resistance to cytotoxic drugs has improved enormously with the recent determination of the structures of three Escherichia coli transporters, two belonging to the ATP-binding cassette (ABC) superfamily and one to the resistance-nodulation-cell division (RND) family. Although these studies do not provide an insight into how drug pumps can recognize several structurally unrelated drugs, important advances have been also made in this area. Information on the molecular basis of multidrug recognition has been provided by determining the structure of transcriptional regulators that can bind, often structurally unrelated, cytotoxic drugs and control the expression of drug pumps.

    PMID:
    12526851
    [PubMed - indexed for MEDLINE]

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