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Annu Rev Med. 2003;54:169-84. Epub 2001 Dec 3.

The hypereosinophilic syndrome revisited.

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  • 1Department of Internal Medicine Universit√© Libre de Bruxelles, B-1070 Brussels, Belgium. froufoss@ulb.ac.be


Clinical and biological features of patients with the idiopathic hypereosinophilic syndrome (HES) are heterogeneous. Recent evidence suggests at least two distinct underlying hematological disorders involving myeloid and lymphoid cells, respectively. We therefore suggest that the term idiopathic should be abandoned in the classification of HES. This review defines the "myeloproliferative" and "lymphocytic" variants of the HES and addresses the management of each variant, focusing on diagnosis and treatment of the newly identified lymphocytic variant.

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