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J Virol. 2003 Feb;77(3):2251-7.

Frequency and phenotype of circulating Valpha24/Vbeta11 double-positive natural killer T cells during hepatitis C virus infection.

Author information

  • 1Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, United Kingdom.

Abstract

Natural killer T (NKT) cells are thought to be involved in innate responses against infection. We investigated one specific type of NKT cell, Valpha24/Vbeta11 double positive, in hepatitis C virus (HCV) infection. Lower frequencies of this population were detected in the blood of HCV PCR-positive patients than in controls. Unlike Valpha24/Vbeta11 NKT cells found in blood, those in the liver appeared to be recently activated.

PMID:
12525661
[PubMed - indexed for MEDLINE]
PMCID:
PMC140901
Free PMC Article

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