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Fertil Steril. 2003 Jan;79(1):96-9.

Estrogen receptor thymine-adenine dinucleotide repeat polymorphism is associated with susceptibility to leiomyoma.

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  • 1Department of Obstetrics and Gynecology, China Medical College Hospital, Taichung, Taiwan.

Abstract

OBJECTIVE:

To evaluate the association between leiomyomas and estrogen receptor gene polymorphism.

DESIGN:

Prospective study.

SETTING:

Department of gynecology and genetics.

PATIENT(S):

Women with (n = 159) or without leiomyomas (n = 131).

MAIN OUTCOME MEASURE(S):

Polymerase chain reaction was used to detect dinucleotide (thymine-adenine [TA]) repeat polymorphisms upstream of the estrogen receptor gene. Genotypes were classified as A through P according to the number of the TA repeats from 12 to 27. Distributions of TA repeat for estrogen receptor in both groups were compared.

RESULT(S):

Genotypes A to E were detected in 10.7%, 18.9%, 15.7%, 16.4%, and 4.4%, respectively, of women with leiomyomas and 4.2%, 9.5%, 20.6%, 19.1%, and 10.3% of women without leiomyomas. Women with genotypes A and B (12 or 13 TA repeats) have a higher risk for leiomyomas, and those with genotype E (16 TA repeats) have a lower risk.

CONCLUSION(S):

Estrogen receptor gene polymorphism probably contributes to the pathogenesis of leiomyoma and may predict the susceptibility to leiomyoma. The 12 and 13 TA repeats are associated with a higher risk of leiomyoma.

PMID:
12524070
[PubMed - indexed for MEDLINE]
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