Pharmacotherapy. 2003 Jan;23(1):97-100.

Celecoxib in human milk: a case report.

Knoppert DC, Stempak D, Baruchel S, Koren G.

Source

Department of Pharmacy, St Joseph's Hospital, Department of Paediatrics, University of Western Ontario, London, Ontario, Canada. dave.knoppert@sjhc.london.on.ca

Abstract

Many women of reproductive age take the nonsteroidal antiinflammatory drug celecoxib. No data exist, however, regarding its transfer into human breast milk and safety for breastfed infants. We had the opportunity to obtain such data when a woman who was breastfeeding her infant daughter underwent emergency surgery to remove a gangrenous appendix. She received four doses of oral celecoxib 100 mg and did not breastfeed her daughter for 48 hours after taking the last dose. We analyzed samples of her breast milk and found a concentration of 133 ng/ml at approximately 5 hours after a 100-mg dose and an elimination half-life of 4.0-6.5 hours. This initial report, which should be substantiated and expanded, provides information that can help counsel parents about breastfeeding and celecoxib.

PMID:: 12523466; [PubMed - indexed for MEDLINE]

Free full text

Publication Types, MeSH Terms, Substances

Publication Types

Case Reports

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Molecular Biology Databases

CELECOXIB - HSDB

Supplemental Content

Save items

Related citations in PubMed

Transfer of celecoxib into human milk. [J Hum Lact. 2004]
Transfer of celecoxib into human milk.
Hale TW, McDonald R, Boger J. J Hum Lact. 2004 Nov; 20(4):397-403.
Quantification of infant exposure to celecoxib through breast milk. [Br J Clin Pharmacol. 2006]
Quantification of infant exposure to celecoxib through breast milk.
Gardiner SJ, Doogue MP, Zhang M, Begg EJ. Br J Clin Pharmacol. 2006 Jan; 61(1):101-4.
RE: "Transfer of celecoxib into human milk". [J Hum Lact. 2007]
RE: "Transfer of celecoxib into human milk".
Ruhlen RL, Chen YC, Rottinghaus GE, Sauter ER. J Hum Lact. 2007 Feb; 23(1):13-4.
Review Drug excretion into breast milk--overview. [Adv Drug Deliv Rev. 2003]
Review Drug excretion into breast milk--overview.
Ito S, Lee A. Adv Drug Deliv Rev. 2003 Apr 29; 55(5):617-27.
Review SSRIs during breastfeeding: spotlight on milk-to-plasma ratio. [Arch Womens Ment Health. 2007]
Review SSRIs during breastfeeding: spotlight on milk-to-plasma ratio.
Gentile S, Rossi A, Bellantuono C. Arch Womens Ment Health. 2007; 10(2):39-51. Epub 2007 Feb 12.

See reviews... See all...

Cited by 1 PubMed Central article

Quantification of infant exposure to celecoxib through breast milk. [Br J Clin Pharmacol. 2006]
Quantification of infant exposure to celecoxib through breast milk.
Gardiner SJ, Doogue MP, Zhang M, Begg EJ. Br J Clin Pharmacol. 2006 Jan; 61(1):101-4.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Celecoxib in human milk: a case report.
Celecoxib in human milk: a case report.
Pharmacotherapy. 2003 Jan ;23(1):97-100.

PubMed
Skin necrosis following warfarin therapy.
Skin necrosis following warfarin therapy.
Br J Dermatol. 1976 Jan ;94(1):97-9.

PubMed
Tenofovir: a nucleotide analog for the management of human immunodeficiency viru...
Tenofovir: a nucleotide analog for the management of human immunodeficiency virus infection.
Pharmacotherapy. 2003 Jan ;23(1):29-43.

PubMed
Flow perfusion culture of marrow stromal osteoblasts in titanium fiber mesh.
Flow perfusion culture of marrow stromal osteoblasts in titanium fiber mesh.
J Biomed Mater Res A. 2003 Feb 1 ;64(2):235-41.

PubMed
Mutational analysis in longest known survivor of mucopolysaccharidosis type VII.
Mutational analysis in longest known survivor of mucopolysaccharidosis type VII.
Hum Genet. 2003 Feb ;112(2):190-4. Epub 2002 Nov 5 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: