This paper is the result of our experience in clinical oncology in which we verified the lack of systematization in the nursing assistance offered to oncological patients. Thus, the objectives of this study are to analyze the problems of patients undergoing antineoplasic chemotherapy; identify the need for home nursing care; implement a systematic home assistance in order to continue the post-chemotherapy care and analyze the proposal of a systematic assistance. It was concluded that a specialized, systematic, whole, continuous and holistic assistance, extended to the patients' homes, minimizes complications associated to the side effects of antineoplasic chemotherapy.