Science. 1976 Feb 13;191(4227):561-2.

Brain acetylcholine: control by dietary choline.

Abstract

Acetylcholine concentrations in whole rat brain or in various brain regions and free choline concentrations in blood serum and brain vary with dietary choline consumption. The increases in brain acetylcholine after treatment with physositigmine (an inhibitor of actylcholinesterase) or after consumption of a diet high in choline are additive, suggesting that choline acts by increasing acetylcholine synthesis.

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Effects of dietary choline on nicotinic acetylcholine receptors in brain. [Nature. 1977]
Effects of dietary choline on nicotinic acetylcholine receptors in brain.
Morley BJ, Robinson GR, Brown GB, Kemp GE, Bradley RJ. Nature. 1977 Apr 28; 266(5605):848-50.
Lecithin consumption increases acetylcholine concentrations in rat brain and adrenal gland. [Science. 1978]
Lecithin consumption increases acetylcholine concentrations in rat brain and adrenal gland.
Hirsch MJ, Wurtman RJ. Science. 1978 Oct 13; 202(4364):223-5.
Relationship between choline availability and acetylcholine synthesis in discrete regions of rat brain. [J Neurochem. 1979]
Relationship between choline availability and acetylcholine synthesis in discrete regions of rat brain.
Wecker L, Dettbarn WD. J Neurochem. 1979 Mar; 32(3):961-7.
Review Dietary choline: a limiting factor for the synthesis of acetylcholine by the brain. [Adv Neurol. 1990]
Review Dietary choline: a limiting factor for the synthesis of acetylcholine by the brain.
Wecker L. Adv Neurol. 1990; 51:139-45.
Review The source of choline for acetylcholine synthesis in brain. [Life Sci. 1976]
Review The source of choline for acetylcholine synthesis in brain.
Freeman JJ, Jenden DJ. Life Sci. 1976 Oct 1; 19(7):949-61.

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Cited by 15 PubMed Central articles

Short-term nutritional folate deficiency in rats has a greater effect on choline and acetylcholine metabolism in the peripheral nervous system than in the brain, and this effect escalates with age. [Nutr Res. 2010]
Short-term nutritional folate deficiency in rats has a greater effect on choline and acetylcholine metabolism in the peripheral nervous system than in the brain, and this effect escalates with age.
Crivello NA, Blusztajn JK, Joseph JA, Shukitt-Hale B, Smith DE. Nutr Res. 2010 Oct; 30(10):722-30.
Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity. [J Biol Chem. 2010]
Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity.
Jacobs RL, Zhao Y, Koonen DP, Sletten T, Su B, Lingrell S, Cao G, Peake DA, Kuo MS, Proctor SD, et al. J Biol Chem. 2010 Jul 16; 285(29):22403-13. Epub 2010 May 7.
An analysis of licking microstructure in three strains of mice. [Appetite. 2010]
An analysis of licking microstructure in three strains of mice.
Johnson AW, Sherwood A, Smith DR, Wosiski-Kuhn M, Gallagher M, Holland PC. Appetite. 2010 Apr; 54(2):320-30. Epub 2009 Dec 16.

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Brain acetylcholine: control by dietary choline.

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