Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nat Rev Genet. 2003 Jan;4(1):50-60.

The evolutionary genomics of pathogen recombination.

Author information

  • 1Section of Evolution and Ecology, University of California at Davis, California 95616, USA. pawadalla@ucdavis.edu

Abstract

A pressing problem in studying the evolution of microbial pathogens is to determine the extent to which these genomes recombine. This information is essential for locating pathogenicity loci by using association studies or population genetic approaches. Recombination also complicates the use of phylogenetic approaches to estimate evolutionary parameters such as selection pressures. Reliable methods that detect and estimate the rate of recombination are, therefore, vital. This article reviews the approaches that are available for detecting and estimating recombination in microbial pathogens and how they can be used to understand pathogen evolution and to identify medically relevant loci.

PMID:
12509753
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk