Curr Top Dev Biol. 2003;53:1-114.

Developmental roles and clinical significance of hedgehog signaling.

Source

Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA. amcmahon@mcb.harvard.edu

Abstract

Cell signaling plays a key role in the development of all multicellular organisms. Numerous studies have established the importance of Hedgehog signaling in a wide variety of regulatory functions during the development of vertebrate and invertebrate organisms. Several reviews have discussed the signaling components in this pathway, their various interactions, and some of the general principles that govern Hedgehog signaling mechanisms. This review focuses on the developing systems themselves, providing a comprehensive survey of the role of Hedgehog signaling in each of these. We also discuss the increasing significance of Hedgehog signaling in the clinical setting.

PMID:: 12509125; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Other Literature Sources

Supplemental Content

Related citations

Review Decoding the Hedgehog signal in animal development. [Cell Mol Life Sci. 2006]
Review Decoding the Hedgehog signal in animal development.
Jia J, Jiang J. Cell Mol Life Sci. 2006 Jun; 63(11):1249-65.
Review Developmental biology informs cancer: the emerging role of the hedgehog signaling pathway in upper gastrointestinal cancers. [Cancer Cell. 2003]
Review Developmental biology informs cancer: the emerging role of the hedgehog signaling pathway in upper gastrointestinal cancers.
Xie K, Abbruzzese JL. Cancer Cell. 2003 Oct; 4(4):245-7.
Review Hedgehog signaling in vertebrate and invertebrate limb patterning. [Cell Mol Life Sci. 2000]
Review Hedgehog signaling in vertebrate and invertebrate limb patterning.
Capdevila J, Johnson RL. Cell Mol Life Sci. 2000 Nov; 57(12):1682-94.
Review Hedgehog signaling in gastrointestinal development and disease. [Curr Mol Med. 2002]
Review Hedgehog signaling in gastrointestinal development and disease.
Harmon EB, Ko AH, Kim SK. Curr Mol Med. 2002 Feb; 2(1):67-82.
Review The world according to hedgehog. [Trends Genet. 1997]
Review The world according to hedgehog.
Hammerschmidt M, Brook A, McMahon AP. Trends Genet. 1997 Jan; 13(1):14-21.

See reviews... See all...

Cited by over 100 PubMed Central articles

Shared signaling pathways in normal and breast cancer stem cells. [J Carcinog. 2011]
Shared signaling pathways in normal and breast cancer stem cells.
Malhotra GK, Zhao X, Band H, Band V. J Carcinog. 2011; 10:38. Epub 2011 Dec 31.
A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration. [PLoS One. 2011]
A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration.
McElwain MA, Ko DC, Gordon MD, Fyrst H, Saba JD, Nusse R. PLoS One. 2011; 6(11):e26993. Epub 2011 Nov 1.
Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans. [J Clin Invest. 2011]
Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans.
Ngan ES, Garcia-Barceló MM, Yip BH, Poon HC, Lau ST, Kwok CK, Sat E, Sham MH, Wong KK, Wainwright BJ, et al. J Clin Invest. 2011 Sep; 121(9):3467-78. Epub 2011 Aug 15.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Developmental roles and clinical significance of hedgehog signaling.
Developmental roles and clinical significance of hedgehog signaling.
Curr Top Dev Biol. 2003 ;53:1-114.

PubMed
Lyme disease in pregnancy: case report and review of the literature.
Lyme disease in pregnancy: case report and review of the literature.
Obstet Gynecol Surv. 2007 Jan ;62(1):41-50.

PubMed
Ku's essential role in keeping telomeres intact.
Ku's essential role in keeping telomeres intact.
Proc Natl Acad Sci U S A. 2009 Jul 28 ;106(30):12217-8. Epub 2009 Jul 21 .

PubMed
Changes mimicking new leptomeningeal disease after intensity-modulated radiother...
Changes mimicking new leptomeningeal disease after intensity-modulated radiotherapy for medulloblastoma.
Int J Radiat Oncol Biol Phys. 2009 Jan 1 ;73(1):214-21. Epub 2008 May 15 .

PubMed
A single institution experience with pediatric nasopharyngeal carcinoma: high in...
A single institution experience with pediatric nasopharyngeal carcinoma: high incidence of toxicity associated with platinum-based chemotherapy plus IMRT.
J Pediatr Hematol Oncol. 2007 Jul ;29(7):500-5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: