Cytokine profile in patients with multiple sclerosis following vitamin D supplementation

J Neuroimmunol. 2003 Jan;134(1-2):128-32. doi: 10.1016/s0165-5728(02)00396-x.

Abstract

Multiple sclerosis (MS) patients were randomized, in a double blind design, and placed into either a vitamin D supplemented group or a placebo control group. As expected, serum 25-hydroxyvitamin D levels increased significantly following 6 month vitamin D supplementation (17+/-6 ng/ml at baseline to 28+/-8 ng/ml at 6 months). Vitamin D supplementation also significantly increased serum transforming growth factor (TGF)-beta 1 levels from 230+/-21 pg/ml at baseline to 295+/-40 pg/ml 6 months later. Placebo treatment had no effect on serum TGF-beta 1 levels. Tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma, and interleukin (IL)-13 were not different following vitamin D supplementation. IL-2 mRNA levels decreased following vitamin D supplementation but the differences did not reach significance. Vitamin D supplementation of MS patients for 6 months was associated with increased vitamin D status and serum TGF-beta 1.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cytokines / blood
  • Cytokines / drug effects*
  • Cytokines / immunology
  • Female
  • Humans
  • Immune System / drug effects*
  • Immune System / immunology
  • Immune System / physiopathology
  • Immune Tolerance / drug effects*
  • Immune Tolerance / immunology
  • Inflammation Mediators / blood
  • Inflammation Mediators / immunology
  • Interferon-gamma / genetics
  • Interleukin-13 / genetics
  • Interleukin-2 / genetics
  • Male
  • Multiple Sclerosis / complications
  • Multiple Sclerosis / drug therapy*
  • Multiple Sclerosis / immunology
  • RNA, Messenger / blood
  • RNA, Messenger / drug effects
  • Transforming Growth Factor beta / blood
  • Transforming Growth Factor beta1
  • Treatment Outcome
  • Tumor Necrosis Factor-alpha / genetics
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood
  • Vitamin D / therapeutic use*
  • Vitamin D Deficiency / complications
  • Vitamin D Deficiency / immunology

Substances

  • Cytokines
  • Inflammation Mediators
  • Interleukin-13
  • Interleukin-2
  • RNA, Messenger
  • TGFB1 protein, human
  • Transforming Growth Factor beta
  • Transforming Growth Factor beta1
  • Tumor Necrosis Factor-alpha
  • Vitamin D
  • Interferon-gamma
  • 25-hydroxyvitamin D