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Biochem Biophys Res Commun. 2003 Jan 17;300(3):619-23.

EMI domains are widespread and reveal the probable orthologs of the Caenorhabditis elegans CED-1 protein.

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  • 1Systèmes moléculaires et Biologie structurale, LMCP, CNRS UMR7590, Universités Paris 6 et Paris 7, case 115, 4 place Jussieu, 75252 05 Paris Cedex, France. Isabelle.Callebaut@lmcp.jussieu.fr


The EMI domain, first named after its presence in proteins of the EMILIN family, was identified here in several metazoan proteins with various domain architectures, among which the mammalian NEU1/NG3 proteins and Caenorhabditis elegans CED-1, identified as a transmembrane receptor that mediates cell corpse engulfment. Functional data available for EMILIN proteins suggest that the EMI domain could be a protein-protein interaction module. Sequence profiles specific of the EMI family of domains led to identify the probable orthologs of the C. elegans CED-1 protein in mammals and insects, which were yet uncovered.

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