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Cell. 2002 Dec 27;111(7):919-22.

A web of circadian pacemakers.

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  • 1Department of Molecular Biology, NCCR Frontiers in Genetics, Sciences II, University of Geneva, Switzerland.


The mammalian circadian timing system is composed of almost as many individual clocks as there are cells. These countless oscillators have to be synchronized by a central pacemaker to coordinate temporal physiology and behavior. Recently, there has been some progress in understanding the relationship and communication mechanisms between central and peripheral clocks.

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