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Cell. 2002 Dec 27;111(7):919-22.

A web of circadian pacemakers.

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  • 1Department of Molecular Biology, NCCR Frontiers in Genetics, Sciences II, University of Geneva, Switzerland. ueli.schibler@molbio.unige.ch

Abstract

The mammalian circadian timing system is composed of almost as many individual clocks as there are cells. These countless oscillators have to be synchronized by a central pacemaker to coordinate temporal physiology and behavior. Recently, there has been some progress in understanding the relationship and communication mechanisms between central and peripheral clocks.

PMID:
12507418
[PubMed - indexed for MEDLINE]
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