[The regulatory role of the Hfq protein in bacterial cells]

Iu M Vasil'eva; M B Garber

[The regulatory role of the Hfq protein in bacterial cells]

Mol Biol (Mosk). 2002 Nov-Dec;36(6):970-7.

[Article in Russian]

Authors

Iu M Vasil'eva¹, M B Garber

Affiliation

¹ Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Oblast, 142290 Russia. yuvas@vega.protres.ru

PMID: 12500533

Abstract

Hfq (HF1) is a polyfunctional translational regulator of numerous bacterial mRNAs. Its physico-chemical properties, possible mechanisms regulating bacterial translation, and the effect of Hfq on transcription of several mRNAs are considered. A similarity of Hfq and eukaryotic mRNA splicing proteins is discussed. Data are reviewed on the roles of Hfq in poly(A) metabolism and formation of the bacterial nucleoid and on the Hfq interaction with untranslated regulatory RNAs.

Publication types

English Abstract
Review

MeSH terms

Bacteria / genetics*
Bacteria / metabolism
Bacterial Proteins / genetics
Bacterial Proteins / metabolism
Escherichia coli Proteins / genetics
Escherichia coli Proteins / metabolism
Gene Expression Regulation, Bacterial
Host Factor 1 Protein / genetics
Host Factor 1 Protein / metabolism
Host Factor 1 Protein / physiology*
Poly A / metabolism
Protein Biosynthesis
RNA, Messenger / metabolism
Sigma Factor / genetics
Sigma Factor / metabolism

Substances

Bacterial Proteins
Escherichia coli Proteins
Hfq protein, E coli
Host Factor 1 Protein
RNA, Messenger
Sigma Factor
sigma factor KatF protein, Bacteria
Poly A