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Transplantation. 2002 Dec 27;74(12):1811-2.

Use of oxygenated perfluorocarbon toward making every pancreas count.

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  • 1Diabetes Research Institute, University of Miami Medical School, Miami, FL, USA.


The past few years have seen significant advancement in the clinical relevance of intraportal islet cell transplantation for treatment of type 1 diabetes mellitus. The implementation of novel protocols, such as the one developed by the group of Shapiro and collaborators in Edmonton, has revitalized the enthusiasm for cellular transplantation as a treatment for diabetes by improving the success rates and long-term function of islet grafts. Improved results in clinical islet transplantation reported by the groups in Edmonton, Miami, and Minneapolis have re-proposed the much simpler outpatient cell transplant procedure as an alternative to the more risky and technically challenging whole-organ pancreas transplantation.

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