Objective: Systemic inflammatory response syndrome (SIRS) without infection is a well known phenomenon that accompanies various acute cerebral insults. We in tented to determine whether SIRS was associated with outcome in patients with spontaneous intracerebral hemorrhage.
Patients and methods: In patients with intracerebral hemorrhage, the occurrence of SIRS was assessed according to the guidelines of the 1992 Consensus Conference. SIRS criteria and other prognostic parameters were evaluated as predictors of final outcome.
Results: SIRS was highly related to poor clinical grade (Glasgow coma scale), hemorrhage volume on CT scan and intraventricular extension of hemorrhage. By univariate analysis,the occurrence of SIRS was associated with higher mortality and morbidity rates than was the nonoccurrence (p<0.005).
Conclusions: In patients with intracerebral hemorrhage, SIRS reflected the extent of tissue damage and predicted a poor outcome.