Amphiregulin is expressed in primary cultures of prostate myofibroblasts, fibroblasts, epithelial cells, and in prostate tissue

N Tørring; B S Sørensen; S T Bösch; H Klocker; E Nexø

doi:10.1038/sj.pcan.4500250

Amphiregulin is expressed in primary cultures of prostate myofibroblasts, fibroblasts, epithelial cells, and in prostate tissue

Prostate Cancer Prostatic Dis. 1998 Sep;1(5):262-267. doi: 10.1038/sj.pcan.4500250.

Authors

N Tørring¹, B S Sørensen, S T Bösch, H Klocker, E Nexø

Affiliation

¹ [1] Department of Clinical Biochemistry-KH, University Hospital of Aarhus, Denmark [2] Department of Urology, University of Innsbruck, Austria.

PMID: 12496886
DOI: 10.1038/sj.pcan.4500250

Abstract

The effect and expression of amphiregulin, a growth factor of the EGF-system was investigated in prostate primary cell cultures and in human prostate tissue. Amphiregulin increases proliferation in primary cultures of prostate myofibroblasts grown in serum-free medium. Amphiregulin mRNA is expressed in high amounts in primary cell cultures of prostate myofibroblasts, fibroblasts, epithelial cells, and in samples of prostate tissue. The data are supported by Western-blotting of amphiregulin in prostate myofibroblasts. These data call for a refocus of the expression and effects of the EGF system in the prostate.