Production of macrophage inflammatory protein 3alpha (MIP-3alpha) (CCL20) and MIP-3beta (CCL19) by human peripheral blood neutrophils in response to microbial pathogens

Tohru Akahoshi; Takeshi Sasahara; Rie Namai; Toshimichi Matsui; Hiroyuki Watabe; Hidero Kitasato; Matsuhisa Inoue; Hirobumi Kondo

doi:10.1128/IAI.71.1.524-526.2003

Production of macrophage inflammatory protein 3alpha (MIP-3alpha) (CCL20) and MIP-3beta (CCL19) by human peripheral blood neutrophils in response to microbial pathogens

Infect Immun. 2003 Jan;71(1):524-6. doi: 10.1128/IAI.71.1.524-526.2003.

Authors

Tohru Akahoshi¹, Takeshi Sasahara, Rie Namai, Toshimichi Matsui, Hiroyuki Watabe, Hidero Kitasato, Matsuhisa Inoue, Hirobumi Kondo

Affiliation

¹ Department of Laboratory Medicine, Kitasato University School of Medicine, Kanagawa, Japan. akahoshi@med.kitasato-u.ac.jp

Abstract

Effects of bacterial pathogens on the production of macrophage inflammatory protein 3alpha (MIP-3alpha) and MIP-3beta from human peripheral blood neutrophils were investigated. Neutrophils produced both chemokines by coincubation with either gram-positive or gram-negative bacteria. Neutrophils may initiate antigen-specific immune responses through the release of these chemokines that are capable of promoting selective recruitment of dendritic cells and T-cell subsets.

MeSH terms

Chemokine CCL20
Chemokines, CC / biosynthesis*
Chemokines, CC / metabolism
Gram-Negative Bacteria / immunology*
Gram-Positive Bacteria / immunology*
Humans
Macrophage Inflammatory Proteins / biosynthesis*
Macrophage Inflammatory Proteins / metabolism
Neutrophils / immunology
Neutrophils / metabolism*
Receptors, CCR6
Receptors, Chemokine*

Substances

CCL20 protein, human
CCR6 protein, human
Chemokine CCL20
Chemokines, CC
Macrophage Inflammatory Proteins
Receptors, CCR6
Receptors, Chemokine