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Biochem J. 2003 Mar 1;370(Pt 2):361-71.

Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm.

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  • 1Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093-0640, USA.


Phosphorylation plays a central role in regulating the activation and signalling lifetime of protein kinases A, B (also known as Akt) and C. These kinases share three conserved phosphorylation motifs: the activation loop segment, the turn motif and the hydrophobic motif. This review focuses on how phosphorylation at each of these sites regulates the maturation, signalling and down-regulation of PKC as a paradigm for how these sites control the function of the ABC kinases.

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