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J Biol Chem. 2003 Feb 28;278(9):7617-23. Epub 2002 Dec 18.

Syndecan-4 associates with alpha-actinin.

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  • 1Department of Cell Biology, University of Alabama, Birmingham, Alabama 35294-0006, USA.


Cell adhesion to the extracellular matrix influences many cellular functions. The integrin family of matrix receptors plays major roles in the formation of adhesions, but other proteins modulate integrin signaling. Syndecan-4, a transmembrane proteoglycan, cooperatively signals with integrins during the formation of focal adhesions. To date, a direct link between syndecan-4 and the cytoskeleton has remained elusive. We now demonstrate by Triton X-100 extraction immunoprecipitation and in vitro binding assays that the focal adhesion component alpha-actinin interacts with syndecan-4 in a beta-integrin-independent manner.

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