Immunol Rev. 2002 Dec;190:146-60.

Genomics-based identification of self-ligands with T cell receptor-specific biological activity.

Source

Michael Heidelberger Division of Immunology, Department of Pathology and NYU Cancer Center, New York, NY 10016, USA.

Abstract

Self-peptide/major histocompatibility complex (MHC) complexes profoundly influence the biology of T lymphocytes. They promote the selection of the T cell receptor (TCR) repertoire in the thymus, maintain the homeostasis of peripheral T cells prior to encounter with antigen, and modify the responsiveness of T cells to foreign antigens. In addition, they can serve as antigens for autoaggressive T cells that induce autoimmune diseases. The complete sequencing of the genomes of human, mouse, and many pathogenic organisms now provides us with a comprehensive list of all possible proteins that may be the source of foreign antigenic and self-peptides. A computational approach using profile-based similarity searches on potential self-MHC-binding peptides can be used to efficiently predict self-peptides with biological activities. The common feature of the identified peptides is similarity to antigen. Thus, self-peptides may form 'hazy' images of the universe of antigens that are used as templates to create and maintain the TCR repertoire.

PMID:: 12493012; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Related citations

Review MHC-derived peptides and the CD4+ T-cell repertoire: implications for autoimmune disease. [Cytokines Cell Mol Ther. 1997]
Review MHC-derived peptides and the CD4+ T-cell repertoire: implications for autoimmune disease.
Baum H, Staines NA. Cytokines Cell Mol Ther. 1997 Jun; 3(2):115-25.
Review The structural interactions between T cell receptors and MHC-peptide complexes place physical limits on self-nonself discrimination. [Curr Top Microbiol Immunol. 2005]
Review The structural interactions between T cell receptors and MHC-peptide complexes place physical limits on self-nonself discrimination.
Wucherpfennig KW. Curr Top Microbiol Immunol. 2005; 296:19-37.
Diversity of T cell repertoire shaped by a single peptide ligand is critically affected by its amino acid residue at a T cell receptor contact. [Proc Natl Acad Sci U S A. 2000]
Diversity of T cell repertoire shaped by a single peptide ligand is critically affected by its amino acid residue at a T cell receptor contact.
Fukui Y, Oono T, Cabaniols JP, Nakao K, Hirokawa K, Inayoshi A, Sanui T, Kanellopoulos J, Iwata E, Noda M, et al. Proc Natl Acad Sci U S A. 2000 Dec 5; 97(25):13760-5.
Homology between an alloantigen and a self MHC allele calibrates the avidity of the alloreactive T cell repertoire independent of TCR affinity. [J Immunol. 2003]
Homology between an alloantigen and a self MHC allele calibrates the avidity of the alloreactive T cell repertoire independent of TCR affinity.
Hornell TM, Myers N, Hansen TH, Connolly JM. J Immunol. 2003 May 1; 170(9):4506-14.
Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes. [Nature. 2002]
Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes.
Stefanová I, Dorfman JR, Germain RN. Nature. 2002 Nov 28; 420(6914):429-34.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Genomics-based identification of self-ligands with T cell receptor-specific biol...
Genomics-based identification of self-ligands with T cell receptor-specific biological activity.
Immunol Rev. 2002 Dec ;190:146-60.

PubMed
Predicting dire outcomes of patients with community acquired pneumonia.
Predicting dire outcomes of patients with community acquired pneumonia.
J Biomed Inform. 2005 Oct ;38(5):347-66. Epub 2005 Mar 17 .

PubMed
Genomic and proteomic analysis of the myeloid differentiation program: global an...
Genomic and proteomic analysis of the myeloid differentiation program: global analysis of gene expression during induced differentiation in the MPRO cell line.
Blood. 2002 Nov 1 ;100(9):3209-20.

PubMed
Using a xenograft model of human breast cancer metastasis to find genes associat...
Using a xenograft model of human breast cancer metastasis to find genes associated with clinically aggressive disease.
Cancer Res. 2005 Jul 1 ;65(13):5578-87.

PubMed
A comprehensive evaluation of multicategory classification methods for microarra...
A comprehensive evaluation of multicategory classification methods for microarray gene expression cancer diagnosis.
Bioinformatics. 2005 Mar 1 ;21(5):631-43. Epub 2004 Sep 16 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Genomics-based identification of self-ligands with T cell receptor-specific biological activity.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Related citations

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information