Format

Send to

Choose Destination
See comment in PubMed Commons below
Isr Med Assoc J. 2002 Nov;4(11):1006-8.

Rituximab for refractory childhood autoimmune hemolytic anemia.

Author information

  • 1Department of Pediatric Hematology/Oncology, University of Michigan, Ann Arbor, MI, USA. dgmotto@umich.edu

Abstract

BACKGROUND:

Chronic childhood autoimmune hemolytic anemia is an uncommon disorder that is associated with significant morbidity. Treatment with high dose steroids, splenectomy and frequent blood transfusions results in a myriad of complications including growth failure, bone demineralization, Cushing's syndrome, immunosuppression, and transfusional hemosiderosis.

OBJECTIVES:

To investigate the efficacy of the monoclonal anti-CD20 antibody, rituximab, in treating children with AIHA.

METHODS:

Four children with chronic AIHA, including two with prior splenectomy, who were dependent on high dose steroids and refractory to other immunosuppressive regimens were treated with four to six weekly doses of rituximab at a dose of 375 mg/m2.

RESULTS:

All four patients became transfusion-independent and were taken off prednisone completely. Adverse effects included infusion-related reactions that were mild, and infectious complications of Pneumocystis carinii pneumonia and varicella pneumonia.

CONCLUSIONS:

Treatment with rituximab appears promising for refractory AIHA; if may obviate the need for prednisone and may result in sustained disease remissions in some patients.

PMID:
12489491
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Israel Medical Association
    Loading ...
    Write to the Help Desk