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Otolaryngol Clin North Am. 2002 Jun;35(3):529-45, vi.

Etiology, pathophysiology of symptoms, and pathogenesis of Meniere's disease.

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  • 1Minnesota Ear, Head, and Neck Clinic, Suite 200, 701 25th Avenue South, Minneapolis, MN 55454, USA. papar001@tc.umn.edu


Endolymphatic hydrops is the pathologic feature associated with Meniere's disease. The development of endolymphatic hydrops appears to arise from multifactorial inheritance with alteration of endolymphatic homeostasis. Various factors associated with the phenomenon of hydrops include functional or anatomic obstruction of endolymphatic flow, malabsorption of endolymph, genetic anomalies, vasodilation, allergy, viral infection, and autoimmunity.

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