Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Science. 2002 Dec 13;298(5601):2211-3.

Role of melanopsin in circadian responses to light.

Author information

  • 1Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA. ruby@stanford.edu

Abstract

Melanopsin has been proposed as an important photoreceptive molecule for the mammalian circadian system. Its importance in this role was tested in melanopsin knockout mice. These mice entrained to a light/dark cycle, phase-shifted after a light pulse, and increased circadian period when light intensity increased. Induction of the immediate-early gene c-fos was observed after a nighttime light pulse in both wild-type and knockout mice. However, the magnitude of these behavioral responses in knockout mice was 40% lower than in wild-type mice. Although melanopsin is not essential for the circadian clock to receive photic input, it contributes significantly to the magnitude of photic responses.

PMID:
12481140
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire
    Loading ...
    Write to the Help Desk