Screening for biologically active metabolites with endosymbiotic bacilli isolated from arthropods

FEMS Microbiol Lett. 2002 Dec 17;217(2):199-205. doi: 10.1111/j.1574-6968.2002.tb11475.x.

Abstract

Endosymbiotic bacteria from the genus Bacillus were isolated from different compartments of the gut of various members of insects (Hexapoda) and millipedes (Diplopoda). They were grown in submerged culture and investigated by biological assays and HPLC-diode array analysis regarding their production of bioactive metabolites, which were isolated and determined in structure. Known compounds and yet unknown derivatives from the primary metabolism were detected, as well as antibacterially and antifungally acting peptide antibiotics.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Antifungal Agents / classification
  • Antifungal Agents / isolation & purification
  • Antimicrobial Cationic Peptides
  • Arthropods / anatomy & histology
  • Arthropods / classification
  • Arthropods / microbiology*
  • Bacillus / chemistry*
  • Bacillus / isolation & purification
  • Bacitracin / isolation & purification
  • Herbicides / classification
  • Herbicides / isolation & purification
  • Hypoxanthine / isolation & purification
  • Models, Molecular
  • Peptides*
  • Symbiosis*
  • Tryptamines / isolation & purification
  • Uracil / isolation & purification

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Antimicrobial Cationic Peptides
  • Herbicides
  • Peptides
  • Tryptamines
  • Bacitracin
  • Hypoxanthine
  • tryptamine
  • Uracil
  • bacillomycin D