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Allergy Asthma Proc. 2002 Sep-Oct;23(5):319-24.

Complement-related diseases.

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  • 1Departments of Medicine, Pediatrics, and Pathology, Division of Allergy Immunology, Nassau University Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554, USA.


This review article will consider some basic aspects of complement biology, address the clinical effects of hereditary complement deficiencies and the role of complement related to host cell entry, pathogenesis of infectious diseases, and apoptosis. The immunomodulation of autoimmune and inflammatory disorders related to complement components, the role of intravenous gamma-globulin and mechanisms of autoimmune urticaria and tolerance will be discussed briefly.

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