Endoscopic retrograde cholangiopancreatography contributed considerably to diagnosis or subsequent management of two cases of sclerosing cholangitis, In the first patient, sequential studies helped to determine the timing and nature of the surgical intervention that was used. In the second patient, the diagnosis was suggested by ERCP, which led to surgical exploration and biopsy of the common bile duct to confirm the diagnosis. The quality of the films obtained in both patients was excellent. We suggest that ERCP is a relatively noninvasive and accurate means of follow-up in cases of sclerosing cholangitis.