Curr Opin Cell Biol. 2002 Dec;14(6):684-91.

A revised picture of the E2F transcriptional network and RB function.

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Massachusetts General Hospital Cancer Center, Laboratory of Molecular Oncology, Charlestown, MA 02129, USA.

Abstract

New techniques have enhanced our picture of E2F regulation. These studies have shed light on the roles played by individual E2F and retinoblastoma family members and implicate these proteins in processes extending well beyond the G1/S transition. One thorny issue remains: do our current molecular models of E2F and retinoblastoma action explain all of the functions of these proteins in vivo?

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A revised picture of the E2F transcriptional network and RB function.

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