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Curr Opin Chem Biol. 2002 Dec;6(6):872-7.

Mimicry of bioactive peptides via non-natural, sequence-specific peptidomimetic oligomers.

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  • 1Department of Chemical Engineering, Northwestern University, Evanston, Illinois 60208, USA.


Non-natural, sequence-specific peptidomimetic oligomers are being designed to mimic bioactive peptides, with potential therapeutic application. Cationic, facially amphipathic helical beta-peptide oligomers have been developed as magainin mimetics. Non-natural mimics of HIV-Tat protein, lung surfactant proteins, collagen, and somatostatin are also being developed. Pseudo-tertiary structure in beta-peptides and peptoids may herald the creation of entirely artificial proteins.

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