Structure. 2002 Dec;10(12):1607-11.

Smads "freeze" when they ski.

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Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA. jpf1@duke.edu

Abstract

The transforming growth factor-beta (TGF-beta) signal is manifest through activated heteromeric Smad complex-mediated transcriptional modulation of target genes that translates into diverse, context-specific biologic effects, such as the potent TGF-beta-initiated cytostatic program. The TGF-beta pathway is effectively antagonized through the direct binding and subsequent repression of activated Smad heteromeric complexes by the Ski family of proto-oncoproteins.

PMID:: 12467567; [PubMed - indexed for MEDLINE]

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