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Ophthalmology. 2002 Dec;109(12):2359-61.

Squamous metaplasia of the canaliculi associated with 5-fluorouracil: a clinicopathologic case report.

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  • 1Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.

Abstract

OBJECTIVE:

To illustrate a newly recognized histopathologic change in a patient with canalicular obstruction after weekly administration of 5-fluorouracil for colon cancer.

DESIGN:

Interventional case report.

METHODS:

A full-thickness section of canaliculus was obtained during surgical repair.

MAIN OUTCOME MEASURE:

Histopathologic changes in the specimen.

RESULTS:

The prominent histologic feature of the canalicular specimen was severe squamous metaplasia with narrowing of the lumen.

CONCLUSION:

Canalicular obstruction may follow systemic use of 5-fluorouracil due to squamous metaplasia.

PMID:
12466185
[PubMed - indexed for MEDLINE]
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