Cell Signal. 2003 Feb;15(2):141-9.

Intracellular signals involved in the effects of insulin-like growth factors and neuregulins on myofibre formation.

Zorzano A, Kaliman P, Gumà A, Palacín M.

Source

Facultat de Biologia, Departament de Bioqui;mica i Biologia Molecular, Universitat de Barcelona, Avda. Diagonal 645, E-08028, Barcelona, Spain. azorzano@porthos.bio.ub.es

Abstract

A number of extracellular factors are involved in the embryonic development of skeletal muscle and the muscle regeneration that is triggered in response to muscle damage. Some of them, such as insulin-like growth factors (IGFs), fibroblast growth factors (FGFs), hepatocyte growth factor (HGF), transforming growth factor (TGF)-like molecules, leukemia inhibitor factor (LIF) or platelet-derived growth factors (PDGFs), are involved in the activation of cell proliferation that operates before muscle differentiation. In addition, factors such as IGFs, neuregulins (NRGs), sonic hedgehog (Shh) or Wnt promote muscle differentiation. Here, we review the intracellular signals that are triggered in the myogenic effect of IGFs and neuregulin and we describe common pathways. A fuller understanding of the signalling pathways triggered by these factors may permit the design of new tools for muscle regeneration therapy.

PMID:: 12464385; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Save items

Related citations in PubMed

IGFs, insulin, Shh, bFGF, and TGF-beta1 interact synergistically to promote somite myogenesis in vitro. [Dev Biol. 2000]
IGFs, insulin, Shh, bFGF, and TGF-beta1 interact synergistically to promote somite myogenesis in vitro.
Pirskanen A, Kiefer JC, Hauschka SD. Dev Biol. 2000 Aug 15; 224(2):189-203.
Review Muscle regeneration: cellular and molecular events. [In Vivo. 2009]
Review Muscle regeneration: cellular and molecular events.
Karalaki M, Fili S, Philippou A, Koutsilieris M. In Vivo. 2009 Sep-Oct; 23(5):779-96.
Review Growth factors in skeletal muscle regeneration. [Cytokine Growth Factor Rev. 1996]
Review Growth factors in skeletal muscle regeneration.
Husmann I, Soulet L, Gautron J, Martelly I, Barritault D. Cytokine Growth Factor Rev. 1996 Oct; 7(3):249-58.
Embryonic myogenesis pathways in muscle regeneration. [Dev Dyn. 2004]
Embryonic myogenesis pathways in muscle regeneration.
Zhao P, Hoffman EP. Dev Dyn. 2004 Feb; 229(2):380-92.
Review Hepatocyte growth factor and neuregulin in mammary gland cell morphogenesis. [Adv Exp Med Biol. 2000]
Review Hepatocyte growth factor and neuregulin in mammary gland cell morphogenesis.
Niemann C, Brinkmann V, Birchmeier W. Adv Exp Med Biol. 2000; 480:9-18.

See reviews... See all...

Cited by 2 PubMed Central articles

Skeletal muscle tissue engineering: a maturation model promoting long-term survival of myotubes, structural development of the excitation-contraction coupling apparatus and neonatal myosin heavy chain expression. [Biomaterials. 2009]
Skeletal muscle tissue engineering: a maturation model promoting long-term survival of myotubes, structural development of the excitation-contraction coupling apparatus and neonatal myosin heavy chain expression.
Das M, Rumsey JW, Bhargava N, Stancescu M, Hickman JJ. Biomaterials. 2009 Oct; 30(29):5392-402. Epub 2009 Jul 22.
Inhibition of mammalian muscle differentiation by regeneration blastema extract of Sternopygus macrurus. [Dev Dyn. 2008]
Inhibition of mammalian muscle differentiation by regeneration blastema extract of Sternopygus macrurus.
Kim HJ, Archer E, Escobedo N, Tapscott SJ, Unguez GA. Dev Dyn. 2008 Oct; 237(10):2830-43.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Intracellular signals involved in the effects of insulin-like growth factors and...
Intracellular signals involved in the effects of insulin-like growth factors and neuregulins on myofibre formation.
Cell Signal. 2003 Feb ;15(2):141-9.

PubMed
Siglecs: sialic-acid-binding immunoglobulin-like lectins in cell-cell interactio...
Siglecs: sialic-acid-binding immunoglobulin-like lectins in cell-cell interactions and signalling.
Curr Opin Struct Biol. 2002 Oct ;12(5):609-15.

PubMed
Calcineurin inhibitors and sirolimus: mechanisms of action and applications in d...
Calcineurin inhibitors and sirolimus: mechanisms of action and applications in dermatology.
Clin Exp Dermatol. 2002 Oct ;27(7):555-61.

PubMed
Chromosomal localization of the chicken and mammalian orthologues of the orphan ...
Chromosomal localization of the chicken and mammalian orthologues of the orphan phosphatase PHOSPHO1 gene.
Anim Genet. 2002 Dec ;33(6):451-4.

PubMed
Relationships among Internet health information use, patient behavior and self e...
Relationships among Internet health information use, patient behavior and self efficacy in newly diagnosed cancer patients who contact the National Cancer Institute's NCI Atlantic Region Cancer Information Service (CIS).
Proc AMIA Symp. 2002 :260-4.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: